TABLE 1.

Microbiological activities of β-lactam antibiotics with strain RYC1000 producing β-lactamases

β-lactamase (TEM type)	MIC (μg/ml)
	AM	CER	CTX	CAZ	ATM	CE
No TEMa	≤32	4	0.03	≤0.06	≤0.015	2
TEM-1	>2,048	32	0.03	0.12	0.06	32
S164 (TEM-12)	>2,048	16	0.12	4	0.25	8
T237	2,048	32	0.03	0.12	0.06	32
K240	>2,048	64	0.03	0.5	0.25	32
S164-T237	1,024	16	0.25	1	0.12	32
S164-K240 (TEM-10)	>2,048	16	0.5	128	16	16
T237-K240	2,048	64	0.06	0.25	0.06	128
S164-T237-K240 (TEM-5)	1,024	32	4	16	2	128

^aStrain RYC1000 containing plasmid pBGS19⁻.