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. 2023 Oct 2;28(19):6907. doi: 10.3390/molecules28196907

Figure 5.

Figure 5

Comparison of the applied treatments with respect to the sum of their day-to-day cumulative PASI scores (a); Evaluation the mice body weight change from day 0 (D0) to day 5 (D5) (b); Evaluation of the spleen to body weight ratio [%] as an indication for systemic exposure of the treatments (c); Evaluation of the IMQ induced acanthosis measured as the epidermis thickness (d); Histological examination by H&E staining of the mice back skin samples (e); Evaluation of the IL-17A release in the mice back skin samples taken on D5 (f). ns/**/***—not significant/p < 0.01/p < 0.001 compared to the No treatment group, red symbols ns/#/##/###—not significant/p < 0.05/p < 0.01/p < 0.001 compared to the Unloaded NP treatment group, ANOVA followed by post-hoc Tukey test. Data are presented as mean ± SD. Scale bar: 100 µm.