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. 2023 Sep 30;15(19):4223. doi: 10.3390/nu15194223

Table 2.

Overall risk of bias by supplement. N represents the total number of studies for each supplement.

Supplement Overall Risk of Bias
Vitamin C
(n = 5)
Low: 4 (80%)
Some concerns: 1 (20%)
High: 0 (0%)
Vitamin D
(n = 29)
Low: 25 (86.2%)
Some concerns: 3 (10.3%)
High: 1 (3.4%)
Vitamin E
(n = 7)
Low: 6 (85.7%)
Some concerns: 0 (0%)
High: 1 (14.3%)
Calcium
(n = 21)
Low: 17 (81.0%)
Some concerns: 2 (9.5%)
High: 2 (9.5%)
Magnesium
(n = 18)
Low: 17 (94.4%)
Some concerns: 1 (5.6%)
High: 0 (0%)
Potassium
(n = 12)
Low: 9 (75%)
Some concerns: 2 (16.7%)
High: 1 (8.3%)

The number of studies obtaining each of the three grades is noted in Column 2, with the percentages reflecting the frequency of each assignment for each supplement.