Table 10.
MICs (in µg/mL) (by broth microdilution) of calixpenams (145 (Pen. X), 146 (Pen. V)), calixcephems (151 (Ceph. X), 152 (Ceph. V)) and their corresponding single penams (147 (Pen. X), 148 (Pen. V)) and cephems (153 (Ceph. X), 154 (Ceph. V)), respectively [157].
| Compounds | ||||||||
|---|---|---|---|---|---|---|---|---|
| Reference Strains |
145 (Pen. X) |
146 (Pen. V) |
147 (Pen. X) |
148 (Pen. V) |
151 (Ceph. X) |
152 (Ceph. V) |
153 (Ceph. X) |
154 (Ceph. V) |
|
S. pyogenes ATCC 19615 |
0.002 | 0.003 | 0.012 | 0.016 | nt | nt | nt | nt |
|
S. agalactiae ATCC 12386 |
0.004 | 0.006 | 0.025 | 0.032 | nt | nt | nt | nt |
|
S. pneumoniae ATCC 49619 |
0.022 | 0.024 | 0.125 | 0.125 | nt | nt | nt | nt |
|
S. aureus ATCC 25923 |
0.025 | 0.032 | nt | nt | 0.225 | 0.25 | 1.775 | 1.550 |
|
S. aureus ATCC 29213 |
0.24 | 0.256 | nt | nt | 0.992 | 1.012 | 5.325 | 5.150 |
|
S. aureus ATCC 11632 |
>64 | >64 | nt | nt | 0.912 | 0.925 | 8.775 | 8.350 |
|
S. aureus ATCC 43300 |
>64 | >64 | nt | nt | 1.150 | 1.225 | 11.775 | 10.950 |
|
S. aureus ATCC 33591 |
>64 | >64 | nt | nt | 1.550 | 1.635 | 16.650 | 16.325 |
nt: not tested.