TABLE 3.
Analysis of MICs for terbinafine and fluconazole against 259 cutaneous isolates of C. albicansa
| MIC of fluconazole (μg/ml) | MIC of terbinafine (μg/ml)
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | >32 | Total | |
| 0.06 | 1 | 1 | 1 | 3 | |||||||||
| 0.125 | 5 | 7 | 4 | 16 | |||||||||
| 0.25 | 2 | 6 | 50 | 25 | 19 | 5 | 2 | 109 | |||||
| 0.5 | 1 | 13 | 23 | 30 | 3 | 2 | 4 | 76 | |||||
| 1 | 4 | 6 | 11 | 4 | 2 | 1 | 1 | 29 | |||||
| 2 | 1 | 3 | 1 | 2 | 1 | 8 | |||||||
| 4 | 1 | 1 | |||||||||||
| 8 | |||||||||||||
| 16 | |||||||||||||
| 32 | |||||||||||||
| 64 | |||||||||||||
| 128 | 1 | 1 | 1 | 3 | |||||||||
| >128 | 1 | 2 | 3 | 2 | 1 | 5 | 14 | ||||||
| Total | 1 | 1 | 2 | 13 | 75 | 62 | 66 | 16 | 7 | 1 | 1 | 14 | 259 |
a
Breakpoints for fluconazole resistance (16) are ≤8 μg/ml (susceptible), 16 to 32 μg/ml (susceptible-dose dependent), and ≥64 μg/ml (resistant). Breakpoints for terbinafine are not available, but for the purposes of discussion a breakpoint of >8 μg/ml is taken to indicate apparent in vitro resistance.