Table 3.

Cytotoxicity of licorice compounds in gastric cell lines and normal gastric cell line.

Compounds	Cell Lines	Dosage	Cytotoxic Outcome/IC50 (μM)
Licochalcone A	GES-1 AGS MKN-28 MKN-45	0, 10, 25, 50 and 100 µM, 48 h	92.7 41.1 42.0 83.7
Licoricidin (LCD)	MCG-803	1.5625, 3.125, 6.25, 12.5, 25, 50, 100, and 200 μM, 24 h	10.41
Glycyrrhizic acid	MGC-803 BGC-823 SGC-7901	0, 0.5, 1, 2, 3, 4 mg/mL, 48 h	≈2 mg/mL
Licoflavone A (LA)	GES-1 SGC-7901 MKN-45 MGC-803	0, 6.25, 12.5, 25, 50, and 100 μM, 24 h	180.30 78.08 43.26 124.50
18β-glycyrrhetinic acid (18β-GA)	SGC-7901 cells	0, 20, 40, 60, 80, 100 and 120 μM, 24 h	cytotoxicity was observed at a concentration > 80 μM
Liquiritin (LIQ)	GES-1 AGS SNU-216	0, 25, 50, 100, 150 and 200 uM, 24 h	cytotoxicity > 150 μM 185.73 198.86