Table 2.
Values of the independent factors and the response-released drug amount expressed as percentage at 8 h under a 15-run, 3-factor, 3-level Box–Behnken factorial design. Data are presented as average ± SD (n = 3).
| Run No. | SA (% w/v) | Ca2+
(% w/v) |
Drop Rate (mL/min) | Released MET at 8 h (%) | Released PIO at 8 h (%) |
|---|---|---|---|---|---|
| 1 | 4.0 | 3.0 | 2.0 | 67.23 ± 2.65 | 71.14 ± 2.40 |
| 2 | 6.0 | 3.0 | 2.0 | 84.76 ± 4.12 | 82.02 ± 1.07 |
| 3 | 4.0 | 9.0 | 2.0 | 58.37 ± 3.91 | 60.11 ± 5.37 |
| 4 | 6.0 | 9.0 | 2.0 | 64.12 ± 2.10 | 65.01 ± 3.82 |
| 5 | 4.0 | 6.0 | 1.0 | 63.87 ± 4.64 | 61.65 ± 2.91 |
| 6 | 6.0 | 6.0 | 1.0 | 71.84 ± 2.06 | 74.02 ± 3.11 |
| 7 | 4.0 | 6.0 | 3.0 | 61.08 ± 7.55 | 58.26 ± 2.35 |
| 8 | 6.0 | 6.0 | 3.0 | 77.68 ± 0.98 | 79.94 ± 4.58 |
| 9 | 5.0 | 3.0 | 1.0 | 61.24 ± 3.16 | 59.70 ± 7.42 |
| 10 | 5.0 | 9.0 | 1.0 | 70.64 ± 3.51 | 72.79 ± 2.08 |
| 11 | 5.0 | 3.0 | 3.0 | 60.03 ± 2.85 | 61.28 ± 0.43 |
| 12 | 5.0 | 9.0 | 3.0 | 55.97 ± 3.77 | 59.15 ± 4.01 |
| 13 | 5.0 | 6.0 | 2.0 | 66.30 ± 5.15 | 66.12 ± 8.29 |
| 14 | 5.0 | 6.0 | 2.0 | 72.14 ± 3.87 | 71.09 ± 3.20 |
| 15 | 5.0 | 6.0 | 2.0 | 69.10 ± 2.54 | 72.42 ± 1.93 |