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. 2023 Oct 7;28(19):6962. doi: 10.3390/molecules28196962

Figure 1.

Figure 1

The pH–solubility of ketoconazole (KTZ) with polyvinylpyrrolidone–vinyl acetate copolymer (PVPVA) or hydroxypropyl methyl-cellulose (HPMC) in biorelevant fluids at 37 °C. The solid lines are the fitted pH–solubility curves through the modified Henderson–Hasselbalch equation. The data points are presented as the mean ± SD (n = 3). * for p < 0.05 and *** for p < 0.001, their color represent the same group as the symbols.