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The profiles of the ketoconazole concentration–time observed in the aqueous phase in the duodenal cup (A), aqueous phase in the jejunal cup (B), organic phase in the duodenal cup (C), and organic phase in the jejunal cup (D). The solubility of ketoconazole in real-time pH was calculated and represented by dashed lines, which matched the color of corresponding data points. The data points are presented as the mean ± SD (n = 3).
