Table 2.
DGIM | USP II | ||||||||
---|---|---|---|---|---|---|---|---|---|
Control | PVPVA | HPMC | Mean | Control | PVPVA | HPMC | Mean | ||
Cmax (ng·mL−1) |
Observation | 41,300 | 48,100 | 45,400 | 41,300 | 48,100 | 45,400 | ||
Prediction | 45,529 | 54,269 | 48,488 | 45,702 | 58,480 | 57,044 | |||
PE (%) | 10.24 | 12.83 | 6.80 | 9.96 | 10.66 | 21.58 | 25.65 | 19.3 | |
AUC (h·ng·mL−1) |
Observation | 112,853 | 146,143 | 135,015 | 112,853 | 146,144 | 135,015 | ||
Prediction | 114,652 | 144,456 | 135,032 | 108,727 | 149,731 | 126,032 | |||
PE (%) | 1.59 | −1.16 | 0.01 | 0.92 | −3.66 | 2.45 | −6.65 | 4.25 |