Ar	Aryl
CDCl3	Deuterated chloroform
CHARMm	Chemistry at Harvard Macromolecular Mechanics
CNS	Central nervous system
DCM	Dichloromethane or methylene chloride
ESI	Electrospray ionization
GPCR	G-protein-Coupled Receptor
mGluR	Metabotropic glutamate receptor
HPLC	High-performance liquid chromatography
HRMS	High-resolution mass spectrometry
IP	Isolated and purified yield
LDA	Lithium diisopropyl amide
LiHMDS	Lithium hexamethyl disilazide
LM&EQ	Lateral metalation and electrophilic quenching
MHz	Mega Hertz
MS	Mass spectrometry
NMR	Nuclear magnetic resonance
ON	Overnight
PDB	Protein data bank
PTSA	p-Toluenesuflonic acid
RMS	Root mean squared gradient
RSM	Yield based on recovered starting material
7TM	Seven-transmembrane receptor
THF	tetrahydro furan
[3,4-d] isoxazolo	[3,4-d] pyridazinone
VFD	Venus flytrap domain or glutamate binding domain of mGluR2 and 4