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. 2023 Oct 13;9(41):eade3816. doi: 10.1126/sciadv.ade3816

Fig. 8. Schematic representation of the signaling changes and evaluation of acquired resistance.

Fig. 8.

(A and B) A cartoon representation summarizing the cellular signaling involvement in sotorasib and the evolution of acquired resistant clones under continuous pressure. The cartoons were made using BioRender. PI3K, phosphatidylinositol 3-kinase. MEK, MAPK kinase.