Fig. 5.

Cooccurrence of the different AMR classes (as defined by AMRfinder+), and the point mutations conferring the resistance to quinolone in the RefSeq dataset. The node size represents the number of times the resistance was found across the genomes. The resistances to quinolone conferred by point mutations and by qnr or oqx genes are represented in black and gray, respectively. The edge width represents the number of cooccurrences in a genome. Edges were converted into arrows when the chronologies between acquisition of mutations and the AMR classes were significant (mutations emerging first). When the resistance is conferred by other mechanisms, genes involved are annotated between brackets.