Figure 2.

Historical placebo-arm HIV incidence for HIV prevention efficacy trials in women in SSA, 2011 to 2020 spanning eSwatini, Kenya, Malawi, South Africa, Uganda, Zambia, Zimbabwe, and a counterfactual placebo HIV incidence estimate based on the historical incidence data. The placebo-arm HIV incidence for HVTN 703/HPTN 081 (2016–2020; Botswana, Kenya, Malawi, Mozambique, South Africa, Tanzania, and Zimbabwe) is shown for comparison.

FACTS 001 (ClinicalTrials.gov #NCT01386294)

ASPIRE (ClinicalTrials.gov #NCT01617096)

HVTN 703 (ClinicalTrials.gov #NCT02568215)

Ring Study (IPM 027) (ClinicalTrials.gov #NCT01539226

ECHO (ClinicalTrials.gov #NCT02550067)

HVTN 702 (ClinicalTrials.gov #NCT02968849)