Figure 3.

Historical placebo-arm HIV incidence for HIV prevention efficacy trials in men who have sex with men (MSM), 2004 to 2014 spanning Australia, Brazil, Canada, Dominican Republic, Ecuador, England, France, Haiti, Jamaica, Peru, Puerto Rico, South Africa, Thailand, United States, and a counterfactual placebo HIV incidence estimate based on the historical incidence data. The placebo-arm HIV incidence for HVTN 704/HPTN 085 (2016–2020; United States, Peru, Switzerland, Brazil) is shown for comparison.

HPTN 039 (ClinicalTrials.gov #NCT00076232)

HVTN 502 (ClinicalTrials.gov #NCT00865566)

HVTN 704 (ClinicalTrials.gov #NCT02716675)iPrEx (ClinicalTrials.gov #NCT00458393)

Ipergay (ClinicalTrials.gov #NCT01473472)

PROUD (ClinicalTrials.gov #NCT02065986)