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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: FASEB J. 2023 Nov;37(11):e23251. doi: 10.1096/fj.202301122RR

Figure 1. Acute deletion of Lpcat3 in the liver improves insulin sensitivity in HFD-fed mice.

Figure 1.

A. Growth curve of Lpcat3fl/fl mice fed HFD for 8 weeks followed by retro-orbital injection with AAV8-TBG-eGFP or AAV8-TBG-iCre (n=6–7/group).

B-C. Body weight and body composition in AAV injected HFD fed mice.

D. Lpcat3 mRNA levels in the liver and adipose tissues in AAV injected HFD fed mice.

E-H. GTT, ITT and area under the curve (AUC) analysis in HFD-fed Lpcat3fl/fl mice injected with AAV8-TBG-eGFP or AAV8-TBG-iCre (n=6–7/group).

I-K. Fasting blood glucose (I), serum insulin levels (J) and HOMA-IR (K) of HFD-fed Lpcat3fl/fl mice injected with AAV8-TBG-eGFP or AAV8-TBG-iCre (n=6–7/group).

Data are represented as means ± SEM. Statistical analysis was performed with two-way ANOVA (C, E and G) and Student’s t test (B, D, F, H-K). *P < 0.05, **P < 0.01, ****P < 0.0001.