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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: FASEB J. 2023 Nov;37(11):e23251. doi: 10.1096/fj.202301122RR

Figure 2. Acute deletion of Lpcat3 in the liver improves hypertriglyceridemia in HFD-fed mice.

Figure 2.

A. Expression of selected genes in the livers of HFD-fed Lpcat3fl/fl mice injected with AAV8-TBG-eGFP or AAV8-TBG-iCre (n=6–7/group).

B-E. Serum triglyceride (B) and NEFA (C) levels and liver triglyceride (D) and NEFA (E) levels of HFD-fed Lpcat3fl/fl mice injected with AAV8-TBG-eGFP or AAV8-TBG-iCre.

F. Representative histology of liver, epididymal white adipose tissue (eWAT), subcutaneous white adipose tissue (sWAT) from HFD-fed Lpcat3fl/fl mice injected with AAV8-TBG-eGFP or AAV8-TBG-iCre. Scale bar: 100 μm.

G-H. Energy expenditure (EE) analyzed by regression analysis of covariance (ANCOVA).

I. EE estimated by univariate generalized linear model (GLM) with body mass set to 42.92 g (average body mass of AAV8-TBG-eGFP or AAV8-TBG-iCre injected mice on HFD).

J-L. Food consumption (J), physical activity (K) and respiratory exchange ratio (RER) (L) in HFD-fed Lpcat3fl/fl mice injected with AAV8-TBG-eGFP or AAV8-TBG-iCre.

Data are presented as means ± SEM. Statistical analysis was performed with Student’s t test (A-E, J), ANCOVA (G-H), and two-way ANOVA (I, K, L). *P < 0.05, **P < 0.01, ****P < 0.0001.