Figure 5. Whole-body silencing Lpcat3 expression alters phospholipid composition in metabolic organs.

A. Expression of Lpcat3 in different tissues of HFD-fed C57BL/6 mice subcutaneously injected with control and Lpcat3 targeting ASOs (n=6–12/group).
B-E. PC composition in the liver, muscle, WAT and BAT of HFD-fed mice injected with ASO (n=5/group).
F. Serum FGF21 levels in HFD-fed mice injected with ASO (n=10/group).
Data are presented as means ± SEM. Statistical analysis was performed with Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.