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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: FASEB J. 2023 Nov;37(11):e23251. doi: 10.1096/fj.202301122RR

Figure 8. Global suppression of Lpcat3 has no effect on lipid metabolism in ob/ob mice.

Figure 8.

A-D. Serum triglyceride (A) and NEFA (B) levels and liver triglyceride (C) and NEFA (D) levels of ob/ob mice injected with Con-ASO or Lpcat3-ASO.

E. Expression of selected genes in the livers of ob/ob mice injected with Con-ASO or Lpcat3-ASO (n=7–8/group).

F. Representative histology of liver, eWAT and sWAT from ob/ob mice injected with Con-ASO or Lpcat3-ASO. Scale bar: 100 μm.

G-H. Energy expenditure (EE) analyzed by regression analysis of covariance (ANCOVA).

I. EE estimated by univariate generalized linear model (GLM) with body mass set to 44.5 g (average body mass of Con-ASO or Lpcat3-ASO injected ob/ob mice).

J-K. Physical activity (J) and respiratory exchange ratio (RER) (K) in ob/ob mice injected with Con-ASO or Lpcat3-ASO.

L. Expression of Lpcat3 and lipases in eWAT of ob/ob mice injected with Con-ASO or Lpcat3-ASO (n=7–8/group).

Data are presented as means ± SEM. Statistical analysis was performed with Student’s t test (A-E), ANCOVA (G-H), and two-way ANOVA (I-K). *P < 0.05, **P < 0.01, ****P < 0.0001.