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. 2023 Oct 16;133(20):e169671. doi: 10.1172/JCI169671

Figure 6. BACH1 expression correlates with angiogenesis gene and protein expression in human NSCLC samples.

Figure 6

(A) Heatmap showing TCGA lung cancer cases with low (left) and high (right) BACH1 expression. Angiogenic genes whose expression differed significantly between the 2 groups are listed on the right along with the P value for the correlation with BACH1 expression. (B) Representative immunohistochemical staining for BACH1, VEGFA, and VEGFR2 in consecutive sections of tumors from patients with KRAS-mutant NSCLC. Tumor sections with low BACH1 expression (left); tumor section with high BACH1 expression (right). Original magnification, ×20. Scale bars: 100 μm. (C) Comparisons of VEGFA and VEGFR2 expression with BACH1 protein expression in human NSCLC tumor sections (n = 20). Data were analyzed using Pearson’s correlation test (C).