Skip to main content
. 2023 Oct 16;133(20):e169671. doi: 10.1172/JCI169671

Figure 7. BACH1 increases tumor vascularity and the response to anti-VEGF therapy in xenografts.

Figure 7

(A) Tumor vascularity (peak enhancement) in NSG mice injected s.c. with 5 × 105 BACH1+/+ or BACH1–/– A549 cells and administrated water (n = 9 and 6 for +/+ and –/–, respectively), 1 g/L NAC (n = 9 and 5), or 3.47 g/L VitC (n = 9 and 7) for 7 weeks. (B) Representative images of tumor vascularity from ultrasound imaging analyses. (C–E) Tumor growth in NSG mice injected s.c. with 5 × 105 BACH1OE (C and D) and BACH1–/– (C and E) A549 cells. When tumors were palpable, the mice were injected i.p. with PBS (n = 6 in D and E) and 40 mg/kg DC101 (D, n = 7; E, n = 6) 3 times per week for 5 weeks. Tumors were measured 3–5 times per week. (F) Curves from D and E are shown in the same graph. Data indicate the mean ± SEM. Statistical significance was determined by 1-way ANOVA with Tukey’s post hoc test for multiple comparisons (A) and 2-way ANOVA with Šidák’s post hoc test for multiple comparisons (F).