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. Author manuscript; available in PMC: 2023 Oct 14.
Published in final edited form as: Oncogene. 2023 Jul 11;42(34):2521–2535. doi: 10.1038/s41388-023-02768-6

Fig. 1. Notch activation is correlated with MDM2 expression and poor prognosis in human liposarcomas.

Fig. 1

A–C Positive correlation of Notch signaling related genes (NOTCH1, HES1) with MDM2 in human well-differentiated liposarcoma (WDLS, n = 13) and dedifferentiated liposarcoma (DDLPS, n = 12). Black dots, WDLPS. Red dots, DDLPS. R, correlation coefficient, and P values were generated using Pearson’s correlation. D, E MDM2 and HEY1 mRNA levels in 7 human liposarcoma cell lines (n = 3). Data are presented as mean ± SD, *P < 0.05, **P < 0.001. F Immunoblots of MDM2 and HES1 proteins in various human liposarcoma cells. G, H Kaplan–Meier curve of overall survival in sarcoma and dedifferentiated liposarcoma patients from the TCGA dataset using cBioPortal platform analysis. The sarcoma samples were segregated into HEY1 amplification (2.4%, n = 5), HEY1 no alterations (n = 201) groups. The dedifferentiated liposarcoma patients were segregated into HEY1 amplification (4%, n = 2), HEY1 no alterations (n = 48). The P value was calculated using a log-rank (Mantel–Cox) test.