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. 2023 Mar 27;28(5):2136–2147. doi: 10.1038/s41380-023-02020-3

Fig. 1. MAR-ASD autoantibody production in rat dams.

Fig. 1

A Autoantibody production is induced in rat dams through injection with autism-specific autoantigen peptides. Antibody can then transfer to offspring and influence developmental outcomes. B Levels of serum IgG Ab reactive to MAR-ASD proteins (LDHA/B, STIP1, CRMP1) in rat dams compared between aAb and control animals. Values expressed as fold-change over baseline (week 0) following 4 weeks of injections. C Longitudinal characterization of MAR-ASD IgG persistence in serum from treated dams at 5 weeks and 60 weeks following initial immunization. ELISA data representative of single experiments. D Serum cytokine levels in MAR-ASD and control dams taken 1 week prior to breeding. Data expressed as fold change over baseline (week 0). N = 3 per condition for each experiment, data are expressed as mean ± SEM. Analysis conducted by two-way ANOVA, representative of a single experiment.