Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 27;28(5):2136–2147. doi: 10.1038/s41380-023-02020-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — A Total brain volume (mm³) in MAR-ASD and Ctrl offspring in both sexes at PND30 and PND70. Data represented as mean ± SD, *p < 0.05, ***p < 0.001. MAR ASD; N = 6/sex, Ctrl; N = 8/sex. B Heatmap plot of absolute and relative regional volumetric differences in MAR-ASD offspring collapsed between time points. Heatmap scale corresponds to Cohen’s F values for the comparisons between MAR-ASD and Ctrl animals for each region. Columns represent data either from both sexes combined (“Both”), or each sex independently. Starred (*) fields represent those comparisons that differed significantly between treatment groups and had a false discovery ratio (FDR) below 5%. Colored blocks on the right y-axis correspond to regional grouping by larger brain areas. Imaging data were analyzed by two-way ANOVA with 5% FDR correction. C Graph of brain regions displaying differences by treatment using relative volumetric analysis. Data expressed as percent change with values collapsed between time point and sex. D Visual representation of brain regions displaying relative volumetric differences in MAR-ASD offspring compared to control animals in males, females, or both sexes combined. Spinal trigeminal nucleus not pictured due to orientation of rendering. Also, subregions within brain area are not broken down (i.e., sensory dysgranular cortex in males) to reduce complexity. All regions are detailed in Supplementary Table 2.