Table 1.
Clinical characteristics of patients with diffuse large B-cell lymphoma.
| Patient characteristics | N of patients (%) Total N = 5126 | |
|---|---|---|
| Age | Median (range) | 68 (18-95) |
| ≤40 | 297 (5.8) | |
| 41–60 | 1191 (23.2) | |
| 61–75 | 2338 (45.6) | |
| >75 | 1300 (25.4) | |
| Gender | Males | 2938 (57.3) |
| Ann Arbor stage | I | 851 (16.6) |
| II | 787 (15.3) | |
| III | 916 (17.9) | |
| IV | 2572 (50.2) | |
| ECOG PS | ≥2 | 857 (16.7) |
| B symptoms | Present | 2143 (41.8) |
| NA | 104 (2.0) | |
| Bulky disease | <7.5 cm | 3324 (64.8) |
| NA | 226 (4.4) | |
| LDH | ≤ ULN | 2295 (44.8) |
| > 1–3xULN | 2344 (45.7) | |
| >3x ULN | 487 (9.5) | |
| EN IPI | >1 | 1620 (31.6) |
| EN NCCN-IPI | ≥1 | 1684 (32.9) |
| Hgb | Grade 2a | 613 (12.0) |
| PLT | <100 × 109/L | 184 (3.6) |
| ALC | ≤0.84 × 109/L | 1190 (23.2) |
| Albumin | <35 g/L | 1545 (30.1) |
ALC absolute lymphocyte count, ECOG PS Eastern Oncology Cooperative Group performance status, EN Extranodal, Hgb hemoglobin, LDH lactate dehydrogenase, NA not applicable, N number, PLT platelets, ULN upper limit of normal.
aAnemia grade 2: Hgb <10–8.0 g/dL (Common Terminology Criteria for Adverse Events—CTCAE).