Table 5.
Summary of hazard ratios, model fit/quality measures, and discrimination measures concerning overall survival.
| HR (95% CI) | AIC | BIC | CPE | AUC | c-index | Difference in c-index | |
|---|---|---|---|---|---|---|---|
| IPI [3] |
Reference 1.858 (1.614; 2.138) 2.659 (2.328; 3.038) 4.758 (4.165; 5.436) |
34340 | 34357 | 0.641 | 0.634 | 0.673 (0.658; 0.687) | –0.020 (–0.028; –0.012) |
| aaIPI [3] |
Reference 1.426 (1.237; 1.643) 1.890 (1.658; 2.153) 2.583 (2.244; 2.974) |
34748 | 34765 | 0.585 | 0.585 | 0.613 (0.601; 0.625) | –0.080 (–0.090; –0.069) |
| NCCN-IPI [8] |
Reference 6.243 (4.182; 9.318) 13.470 (9.057; 20.033) 28.646 (19.156; 42.838) |
34002 | 34019 | 0.670 | 0.657 | 0.693 (0.681; 0.705) | Reference |
| DLBCL-PI [12] |
Reference 1.945 (1.673; 2.262) 2.963 (2.572; 3.414) 6.347 (5.521; 7.297) |
34100 | 34117 | 0.660 | 0.661 | 0.700 (0.688; 0.713) | 0.007 (–0.003; 0.017) |
| aaDLBCL-PI [12] |
Reference 1.331 (1.138; 1.557) 2.171 (1.870; 2.521) 3.540 (3.049; 4.110) |
34527 | 34544 | 0.617 | 0.622 | 0.658 (0.647; 0.668) | –0.035 (–0.046; –0.025) |
| Modified NCCN-IPI [30] |
Reference 2.917 (2.408; 3.532) 5.363 (4.537; 6.339) 12.574 (10.362; 15.258) |
34039 | 34056 | 0.664 | 0.651 | 0.684 (0.674; 0.694) | –0.009 (–0.016; –0.003) |
| KPI [31] |
Reference 1.604 (1.427; 1.803) 3.043 (2.646; 3.500) 4.054 (3.472; 4.734) |
34549 | 34567 | 0.603 | 0.611 | 0.643 (0.635; 0.651) | –0.050 (–0.060; –0.041) |
| Modified 3-factor Model [29] |
Reference 1.827 (1.608; 2.076) 2.752 (2.417; 3.134) 4.669 (3.967; 5.495) |
34538 | 34555 | 0.614 | 0.605 | 0.645 (0.627; 0.662) | –0.048 (–0.058; –0.039) |
| Models with three risk groups | |||||||
| R-IPI [7] |
Reference 6.686 (4.377; 10.210) 14.264 (9.357; 21.740) |
34380 | 34392 | 0.628 | 0.615 | 0.643 (0.635; 0.652) | –0.050 (–0.058; –0.041) |
| Matsumoto Model [33] |
Reference 1.783 (1.608; 1.978) 2.800 (2.429; 3.227) |
34731 | 34742 | 0.580 | 0.576 | 0.598 (0.585; 0.612) | –0.095 (–0.107; –0.083) |
| ALC/R-IPI [28] |
Reference 2.270 (2.059; 2.503) 2.942 (2.611; 3.314) |
34537 | 34548 | 0.611 | 0.606 | 0.642 (0.633; 0.651) | –0.051 (–0.060; –0.042) |
| PA score [32] |
Reference 2.187 (2.004; 2.387) 3.298 (2.611; 4.165) |
34619 | 34631 | 0.584 | 0.588 | 0.612 (0.601; 0.622) | –0.081 (–0.091; –0.071) |
| HP index [34] |
Reference 1.821 (1.670; 1.986) 2.815 (2.348; 3.374) |
34713 | 34725 | 0.577 | 0.577 | 0.602 (0.593; 0.612) | –0.091 (–0.107; –0.074) |
aaDLBCL-PI age-adjusted DLBCL-PI, aaIPI age-adjusted IPI, AIC Akaike Information Criterion, ALC absolute lymphocyte count, AUC area under the curve, BIC Bayesian Information Criterion, c-index concordance index, CPE Concordance probability estimate, DLBCL diffuse large B-cell lymphoma, DLBCL-PI DLBCL Prognostic Index, HP hemoglobin-platelet, IPI International Prognostic Index, KPI Kyoto Prognostic Index, NCCN-IPI National Comprehensive Cancer Network-IPI, PA platelet-albumin, R-IPI Revised International Prognostic Index.
The c-index is not accompanied by a p value in the statistical package used in this article. However, only the model with bold numbers does not differ from the reference model (NCCN-IPI), which can be seen from confidence intervals (CI). To be precise, p value for DLBCL-PI is >0.05, while it is <0.05 for all other models. We do not suggest writing p values in this case, as CI is more precise.