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. 2023 Oct 13;14(10):676. doi: 10.1038/s41419-023-06204-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Scatterplot for hallmark pathways in the PCC population (Red dots indicate the top 3 significantly changed pathways). B GSEA enrichment profile of the top 3 altered hallmark pathways in the proliferated cell population, including Oxidative phosphorylation, MYC targets-V1, and Protein secretion. C Scatterplot for hallmark pathways in the QCC population (blue dots indicate the top 3 significantly changed pathways). D GSEA enrichment profile of the top 3 altered hallmark pathways in the quiescent cell population, including TNFα signaling via NF-kB, Hypoxia, and Cholesterol homeostasis. E Venn plot for overlapping genes involved in corresponding hallmark pathways in PCC and QCC populations. In the QCC population, ATF3, NFIL3 and PNRC1 are co-shared by the corresponding pathways: TNFα signaling via NF-kB, Hypoxia, and Cholesterol homeostasis. F Violin plots of gene expression of ATF3, NFIL3, and PNRC1 in Group 1 (PCCs) and Group 2 (QCCs) (****, p < 0.0001). G Expression levels of ATF3 and ATF4 in HCT116, HT-29, DLD-1 and HEK293T cells under both monolayer and MCTS conditions. H Immunochemistry staining for Ki67, p27 and ATF3 on HCT116 and HEK293T MCTS.