Table 1.

Two-sample Mendelian randomisation estimates of smoking behaviours on CRC risk.

Exposure	No. of IVs	Method	OR (95% CI)	peffect	pheterogeneity	ppleiotropy	R2	F-statistics	Power
AgeSmk	10	IVW	1.34 (0.75, 2.39)	0.330	0.616	–	0.13%	403.52	0.20
		MR Egger	0.94 (0.07, 12.48)	0.966	0.522	0.794
		Weighted median	1.22 (0.58, 2.54)	0.604	–	–
		Simple mode	1.15 (0.31, 4.29)	0.842	–	–
		Weighted mode	1.14 (0.34, 3.84)	0.843	–	–
		MR-PRESSO	1.34 (0.74, 2.41)	0.304	–	–
SmkInit	327	IVW	1.47 (1.24, 1.75)	1.52 × 10−5	5.49 × 10−4	–	1.81%	14,204.16	1.00
		MR Egger	1.89 (0.87, 4.10)	0.109	5.12 × 10−4	0.519
		Weighted median	1.45 (1.15, 1.83)	0.002	–	–
		Simple mode	1.72 (0.76, 3.90)	0.194	–	–
		Weighted mode	1.46 (0.69, 3.11)	0.327	–	–
		MR-PRESSO	1.47 (1.23, 1.76)	2.03 × 10−5	–	–
SmkCes	28	IVW	0.65 (0.43, 0.99)	0.044	0.067	–	0.40%	1504.37	0.76
		MR Egger	0.31 (0.11, 0.90)	0.041	0.096	0.156
		Weighted median	0.77 (0.45, 1.33)	0.346	–	–
		Simple mode	0.76 (0.25, 2.33)	0.638	–	–
		Weighted mode	0.80 (0.32, 2.05)	0.654	–	–
		MR-PRESSO	0.65 (0.42, 1.01)	0.054	–	–
CigDay	60	IVW	1.20 (0.97, 1.48)	0.091	0.031	–	1.44%	4584.08	0.62
		MR Egger	1.09 (0.74, 1.61)	0.670	0.028	0.567
		Weighted median	0.97 (0.72, 1.31)	0.838	–	–
		Simple mode	1.30 (0.59, 2.86)	0.523	–	–
		Weighted mode	1.09 (0.75, 1.60)	0.639	–	–
		MR-PRESSO	1.20 (0.97, 1.49)	0.096	–	–
SmoIndex	120	IVW	1.30 (1.04, 1.62)	0.023	0.033	–	1.07%	4939.85	0.81
		MR Egger	1.30 (0.53, 3.24)	0.569	0.029	0.991
		Weighted median	1.23 (0.91, 1.66)	0.179	–	–
		Simple mode	1.28 (0.54, 3.00)	0.577	–	–
		Weighted mode	1.20 (0.66, 2.18)	0.561	–	–
		MR-PRESSO	1.30 (1.03, 1.63)	0.025	–	–