Table 2.
Univariate and multivariate analysis of overall survival with IGA.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (years) | 1.023 (1.016–1.03) | 8.4e − 11 | 1.03 (1.022 ~ 1.037) | 6.70E − 16 |
| Sex | ||||
| Female | 1.284 (1.098–1.502) | 0.002 | Reference | |
| Male | 1.45 (1.231 ~ 1.708) | 8.40E − 06 | ||
| Marital status | ||||
| Single | 1.104 (0.9796–1.243) | 0.105 | ||
| Married | ||||
| Other | ||||
| Race | ||||
| White | 0.856 (0.784–0.934) | < 0.001 | 1.282 (1.072 ~ 1.533) | 6.50E − 03 |
| Black | 1.33 (1.042 ~ 1.698) | 2.20E − 02 | ||
| Other | Reference | |||
| Surgical methods | ||||
| Local tumor excision | 1.083 (1.012–1.158) | 0.020 | 1.984 (0.863 ~ 4.562) | 1.10E − 01 |
| aGastrectomy | Reference | |||
| bGastrectomy | 1.234 (0.974 ~ 1.562) | 8.20E − 02 | ||
| cGastrectomy | 1.109 (0.874 ~ 1.408) | 4.00E − 01 | ||
| dGastrectomy | 1.173 (0.929 ~ 1.482) | 1.80E − 01 | ||
| Uncertain surgery | 3.988 (2.208 ~ 7.203) | 4.50E − 06 | ||
| Primary site | ||||
| Cardia/Fundus | 0.9786 (0.9026–1.061) | 0.599 | ||
| Body | ||||
| Pylori | ||||
| Other | ||||
| Grade | ||||
| I | 1.408 (1.257–1.578) | 3.4e − 09 | Reference | |
| II | 1.413 (0.995 ~ 2.006) | 5.30E − 02 | ||
| III | 1.532 (1.065 ~ 2.202) | 2.10E − 02 | ||
| IV | 1.241 (0.563 ~ 2.735) | 5.90E − 01 | ||
| Summary stage | ||||
| Localized | 2.146 (1.925–2.393) | < 2e − 16 | Reference | |
| Regional | 1.076 (0.837 ~ 1.384) | 5.70E − 01 | ||
| Distant | 1.636 (1.107 ~ 2.419) | 1.40E − 02 | ||
| AJCC stage | ||||
| I | 1.83 (1.694–1.978) | < 2e − 16 | Reference | |
| II | 1.743 (1.334 ~ 2.277) | 4.70E − 05 | ||
| III | 2.646 (1.893 ~ 3.698) | 1.20E − 08 | ||
| IV | 3.16 (1.986 ~ 5.028) | 1.20E − 06 | ||
| Radiotherapy | ||||
| No | 0.8211 (0.691–0.976) | 0.025 | Reference | |
| Yes | 0.675 (0.56 ~ 0.812) | 3.30E − 05 | ||
| Chemotherapy | ||||
| No | 0.964 (0.8314–1.118) | 0.627 | ||
| Yes | ||||
| RNE | 0.9922 (0.986–0.998) | 0.011 | 0.979 (0.972 ~ 0.985) | 4.00E − 10 |
| RNP | 1.059 (1.049–1.069) | < 2e − 16 | 1.052 (1.035 ~ 1.069) | 3.00E − 10 |
| Tumor size | 1.011 (1.008–1.013) | < 2e − 16 | 1.002 (0.999 ~ 1.005) | 2.70E − 01 |
HR hazard ratio, RNE number of regional nodes examined, RNP number of regional nodes positive, AJCC American-Joint Committee on Cancer.
aPartial, subtotal, hemi-Gastrectomy.
bNear-total or total gastrectomy.
cGastrectomy with removal of a portion of esophagus.
dGastrectomy with a resection in continuity with the resection of other organs; Univariate analysis, Kaplan–Meier analysis; multivariate analysis, cox regression analysis.