Table 3.
Univariate and multivariate analysis of cancer-specific survival with IGA.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (years) | 1.017 (1.009 ~ 1.025) | 4.83E − 05 | 1.019 (1.011 ~ 1.028) | < 0.001 |
| Sex | ||||
| Female | 1.214 (1.007 ~ 1.465) | 0.0423 | Reference | |
| Male | 1.272 (1.047 ~ 1.547) | 0.016 | ||
| Marital status | ||||
| Single | 1.087 (0.945 ~ 1.25) | 0.244 | ||
| Married | ||||
| Other | ||||
| Race | ||||
| White | 0.821 (0.739 ~ 0.912) | < 0.001 | 1.362 (1.093 ~ 1.698) | 0.006 |
| Black | 1.439 (1.087 ~ 1.904) | 0.011 | ||
| Other | Reference | |||
| Surgical methods | ||||
| Local tumor excision | 1.108 (1.022 ~ 1.200) | 0.012 | 1.574 (0.965 ~ 2.567) | 0.069 |
| aGastrectomy | Reference | |||
| bGastrectomy | 1.372 (1.053 ~ 1.788) | 0.019 | ||
| cGastrectomy | 1.133 (0.846 ~ 1.518) | 0.400 | ||
| dGastrectomy | 1.150 (0.866 ~ 1.525) | 0.330 | ||
| Uncertain surgery | 2.390 (0.732 ~ 7.802) | 0.150 | ||
| Primary site | ||||
| Cardia/Fundus | 0.934 (0.846 ~ 1.030) | 0.172 | ||
| Body | ||||
| Pylori | ||||
| Other | ||||
| Grade | ||||
| I | 1.510 (1.318 ~ 1.730) | 3.01E − 09 | Reference | |
| II | 1.725 (1.076 ~ 2.767) | 0.024 | ||
| III | 1.941 (1.197 ~ 3.146) | 0.007 | ||
| IV | 1.170 (0.510 ~ 2.681) | 0.710 | ||
| Summary stage | ||||
| Localized | 2.663 (2.328 ~ 3.045) | < 2e − 16 | Reference | |
| Regional | 1.168 (0.819 ~ 1.666) | 0.390 | ||
| Distant | 1.907 (1.202 ~ 3.025) | 0.006 | ||
| AJCC stage | ||||
| I | 2.240 (2.032 ~ 2.469) | < 2e − 16 | Reference | |
| II | 2.039 (1.378 ~ 3.017) | < 0.001 | ||
| III | 3.991 (2.505 ~ 6.359) | 5.8E − 09 | ||
| IV | 5.012 (2.816 ~ 8.919) | 4.3E − 08 | ||
| Radiotherapy | ||||
| No | 1.029 (0.843 ~ 1.256) | 0.778 | ||
| Yes | ||||
| Chemotherapy | ||||
| No | 1.207 (1.011 ~ 1.44) | 0.037 | Reference | |
| Yes | 0.618 (0.497 ~ 0.769) | < 0.001 | ||
| RNE | 0.988 (0.981 ~ 0.996) | 0.002 | 0.966 (0.957 ~ 0.974) | 2.4E − 14 |
| RNP | 1.075 (1.064 ~ 1.086) | < 2e − 16 | 1.064 (1.046 ~ 1.082) | 6.2E − 13 |
| Size | 1.011 (1.009 ~ 1.014) | 5.8E − 16 | 1.002 (0.998 ~ 1.006) | 0.290 |
HR hazard ratio, RNE number of regional nodes examined, RNP number of regional nodes positive, AJCC American-Joint Committee on Cancer.
aPartial, subtotal, hemi-Gastrectomy.
bNear-total or total gastrectomy.
cGastrectomy with removal of a portion of esophagus.
dGastrectomy with a resection in continuity with the resection of other organs; Univariate analysis, Kaplan–Meier analysis; multivariate analysis, cox regression analysis.