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. 2023 Oct 13;14:6446. doi: 10.1038/s41467-023-41919-x

Fig. 4. Remodelling of the regulatory landscape in GB includes reduction of active marks at enhancers and activation of promoters.

Fig. 4

a Genome-wide integration of all the multi-omics data. b Chromatin states defined by chromHMM in normal astrocytes. c Read distribution of histone marks and ATAC across the various chromatin states in astrocytes and three representative GB lines. d–f Density plots representing the normalized H3K27ac (d), H3K27me3 (e) and RNA-seq (f) signal around the astrocytes’ chromatin states in glioblastoma (blue) vs astrocytes (red).