TABLE 2.

(−)‐MBP negative volume of activation dose response.

Negative BOLD volume of activation
Brain area	3 mg	SE	10 mg	SE	18 mg	SE	p value	ω Sq
Anterior thalamus	0	0.0	0	0.2	8	2.8	.001	0.559
Insular rostral ctx	0	0.3	10	5.7	41	7.7	.001	0.543
Primary motor ctx	0	0.0	0	0.4	4	1.3	.001	0.502
Medial geniculate	0	0.0	2	1.5	5	1.7	.002	0.485
Secondary somatosensory ctx	0	0.0	4	2.9	16	5.2	.003	0.480
Olfactory tubercles	0	0.1	1	1.3	8	2.3	.003	0.451
Corpus callosum	0	0.4	9	3.9	32	6.5	.003	0.469
Primary somatosensory ctx	1	0.5	7	4.4	41	10.4	.003	0.444
Retrosplenial rostral ctx	0	0.0	6	3.7	15	4.8	.004	0.404
Endopiriform area	0	0.0	0	0.1	3	1.9	.005	0.345
Medial dorsal thalamus	0	0.0	0	0.0	2	0.7	.005	0.277
Anterior cingulate area	0	0.0	3	2.1	4	1.4	.006	0.411
Internal capsule	0	0.3	2	1.0	8	3.5	.008	0.372
Rostral piriform ctx	4	4.4	10	6.5	46	11.4	.012	0.323
External capsule	0	0.3	2	1.5	6	1.5	.014	0.326
Frontal association ctx	0	0.3	7	4.9	10	3.3	.018	0.237
Zona incerta	0	0.0	2	1.2	4	1.7	.018	0.290
Central medial thalamus	0	0.0	0	0.0	1	0.4	.024	0.141
Posterior thalamus	0	0.0	0	0.0	1	0.9	.024	0.250
Reticular thalamus	0	0.0	1	0.6	4	2.5	.026	0.257
Pontine reticular n. caudal	2	1.4	1	0.7	8	3.3	.027	0.263
Principal sensory n. trigeminal	2	1.1	4	2.1	19	6.4	.027	0.257
Solitary tract area	2	1.4	1	0.6	11	6.0	.031	0.197
CA1	1	0.9	23	9.6	33	9.2	.031	0.206
Insular caudal ctx	0	0.3	7	3.4	15	4.7	.031	0.263
Ventral thalamus	0	0.0	2	2.4	10	7.7	.032	0.195
CA3	2	1.6	6	2.9	17	6.8	.036	0.196
Caudate putamen	4	2.6	16	10.5	53	22.4	.037	0.225
Granular cell layer	0	0.0	16	12.6	5	2.0	.038	0.206
Inferior colliculus	1	0.5	4	2.5	18	7.5	.038	0.180
3rd cerebellar lobule	0	0.3	2	1.2	7	2.9	.039	0.178
Secondary motor ctx	0	0.0	1	0.4	2	0.7	.039	0.162
Olivary complex	0	0.3	0	0.0	2	1.1	.039	0.146
10th cerebellar lobule	0	0.2	1	0.4	6	3.3	.040	0.193
Auditory ctx	0	0.0	3	1.2	6	2.5	.042	0.203
Dentate gyrus	1	0.8	4	2.0	9	3.2	.044	0.166
Accumbens shell	0	0.0	1	1.0	3	1.5	.049	0.119