TABLE 4.

Dose‐dependent changes in cerebral cortex.

Positive BOLD volume of activation
Brain area	3 mg	SE	10 mg	SE	18 mg	SE	p value	ω Sq
Secondary somatosensory ctx	214	3.1	166	18.3	138	22.7	.001	0.620
Anterior cingulate ctx	123	2.3	88	12.5	75	12.4	.001	0.585
Insular caudal ctx	94	4.4	58	8.1	53	5.4	.001	0.575
Primary somatosensory ctx	782	17.9	683	59.7	585	77.4	.004	0.446
Primary motor ctx	197	11.4	166	21.4	146	21.5	.007	0.382
Auditory ctx	142	5.2	126	7.2	114	9.9	.008	0.369
Rostral piriform ctx	272	12.5	230	28.5	162	19.8	.009	0.358
Retrosplenial rostral ctx	154	4.0	126	12.5	106	17.8	.009	0.358
Insular rostral ctx	196	10.8	162	25.2	116	19.6	.011	0.339
Parietal ctx	13	0.9	8	1.3	9	1.8	.038	0.078
Orbital ctx	191	28.4	184	26.0	153	23.1	.041	0.213