Table 1. Characteristics of the study subjects.
| Total (n=73) | Severe (n=61) | Moderate (n=12) | |
|---|---|---|---|
| Age (years), mean (±SD) | 61.00 (±12.74) | 61.52 (±12.77) | 56.50 (±12.24) |
| Gender | |||
| Male (%) | 47 (64%) | 38 (62%) | 9 (75%) |
| Female (%) | 26 (36%) | 23 (38%) | 3 (25%) |
| Body Mass Index (kg/m 2), median (IQR) | 26.28 (25.10–28.11) | 26.17 (24.96–28.18) | 27.01 (25.98–27.98) |
| Time from illness onset to admission (days), median (IQR) | 6.00 (4.00–7.00) | 6.00 (4.00–7.00) | 6.00 (4.00–7.00) |
| Length of stay (days), median (IQR) | 7 (5–8) | 7 (5–8) | 8 (7–11.75) |
| Final observation outcomes | |||
| Improved (n) | 37 | 26 | 11 |
| Worsening (n) | 36 | 35 | 1 |
| Number of comorbidities | |||
| None | 22 | 20 (33%) | 2 (17%) |
| One comorbidity | 25 | 19 (31%) | 6 (60%) |
| Two comorbidities | 20 | 17 (28%) | 3 (25%) |
| Three comorbidities | 6 | 5 (8%) | 1 (8%) |
| Therapy | |||
| Oseltamivir (n) | 1 | 1 | 0 |
| Favipiravir (n) | 29 | 23 | 6 |
| Remdesivir (n) | 42 | 36 | 6 |
| Meropenem (n) | 52 | 46 | 6 |
| Levofloxacin (n) | 35 | 31 | 4 |
| Azithromycin (n) | 31 | 29 | 2 |
| Enoxaparin (n) | 8 | 6 | 2 |
| UFH (n) | 47 | 43 | 4 |
| Fondaparinux (n) | 17 | 11 | 6 |
| Methylprednisolone (n) | 63 | 55 | 8 |
| Dexamethasone (n) | 8 | 5 | 3 |
| Death | 27 | 27 | 0 |
| Survived | 46 | 34 | 12 |
| First sample collection | |||
| D-dimer (mg/dL), median (IQR) | 1.21 (0.60–2.84) | 1.45 (0.62–2.93) | 0.61 (0.48–1.04) |
| Fibrinogen (mg/dL), median (IQR) | 678.00 (497.00–778.00) | 703.00 (553.00–806.00) | 469.50 (345.75–617.25) |
| Prothrombin time (seconds), median (IQR) | 11.00 (10.00–11.00) | 11.00 (10.00–11.00) | 10.50 (10.00–11.00) |
| Ferritin (ng/mL), median (IQR) | 1505.00 (893.00–2334.00) | 1505.00 (946.00–2334.00) | 1433.00 (599.95–2058.00) |
| IL-6 (pg/mL), median (IQR) | 8.00 (2.07–56.21) | 8.00 (2.07–63.47) | 9.07 (2.40–29.53) |
| SpO 2/ FiO 2 ratio, median (IQR) | 170.18 (141.43–206.25) | 148.48 (139.39–192.16) | 395.24 (330.00–466.67) |
| Second sample collection | |||
| D-dimer (mg/L), median (IQR) | 1.39 (0.85–3.86) | 1.51 (1.03–4.31) | 0.41 (0.32–0.81) |
| Fibrinogen (mg/dL), median (IQR) | 426.00 (342.00–597.00) | 431.00 (352.00–611.00) | 381.00 (327.25–480.50) |
| Prothrombin time (seconds), median (IQR) | 11.00 (11.00–12.00) | 11.00 (11.00–12.00) | 10.50 (10.00–11.00) |
| Ferritin (ng/mL), median (IQR) | 1301.00 (813.00–2187.00) | 1366.00 (933.00–2242.00) | 1003.10 (361.75–1887.00) |
| IL-6 (pg/mL), median (IQR) | 7.39 (1.50–33.26) | 11.63 (2.45–36.54) | 2.20 (0.82–4.50) |
| SpO 2/ FiO 2 ratio, median (IQR) | 111.47 (94.00–394.64) | 97.50 (93.97–247.50) | 408.33 (408.33–411.46) |
Notes: SD: Standard deviation, IQR: Interquartile range, n: number of samples, UFH: unfractionated heparin.