Table 2. Variables' distribution according to disease severity and outcomes.

	Severe		Moderate
	Improved	Worsening	Improved	Worsening
Number of subjects	26	35	11	1
Age (years), median (IQR)	62.00 (47.00–71.75)	62.00 (55.00–69.00)	58.00 (50.50–64.00)	52.00 (52.00–52.00)
Body mass index (kg/m 2), median (IQR)	26.38 (25.17–28.19)	26.17 (24.85–27.85)	27.34 (26.18–28.03)	25.51 (25.51–25.51)
Day of worsening, median (IQR)	7.00 (6.00–7.75)	6.00 (5.00–7.50)	8.00 (7.00–10.00)	18.00 (18.00–18.00)
Time from illness onset to the worsening (days), median (IQR)	14 (13–17)	11 (10–14)	16 (12–18)	18
First sample collection
D-dimer (mg/L), median (IQR)	1.34 (0.51–2.71)	1.50 (0.78–3.37)	0.63 (0.47–1.27)	0.60 (0.60–0.60)
Fibrinogen (mg/dL), median (IQR)	709.50 (515.50–799.00)	678.00 (568.00–808.50)	442.00 (344.50–554.00)	766.00 (766.00–766.00)
Prothrombin time (seconds), median (IQR)	11.00 (10.00–11.00)	11.00 (10.50–11.00)	11.00 (10.00–11.00)	10.00 (10.00–10.00)
Ferritin (ng/mL), median (IQR)	1137.00 (779.75–1799.00)	1906.00 (1361.50–2643.00)	1326.00 (533.70–1747.00)	2436.00 (2436.00–2436.00)
IL-6 (pg/mL), median (RIK)	6.27 (2.55–58.90)	10.78 (1.52–68.31)	12.19 (2.29–33.42)	3.93 (3.93–3.93)
SpO 2/ FiO 2, median (IQR)	179.41 (148.48–196.08)	143.94 (134.85–171.05)	333.33 (330.00–466.67)	457.14 (457.14–457.14)
Second sample collection
D-dimer (mg/L), Median (IQR)	1.19 (0.94–1.64)	3.08 (1.33–9.63)	0.38 (0.32–0.55)	1.63 (1.63–1.63)
Fibrinogen (mg/dL), median (IQR)	406.00 (321.50–492.50)	498.00 (403.00–620.50)	361.00 (326.50–445.50)	491.00 (491.00–491.00)
Prothrombin Time (seconds), median (IQR)	11.00 (10.25–11.00)	11.00 (11.00–12.00)	10.00 (10.00–11.00)	11.00 (11.00–11.00)
Ferritin (ng/mL), median (IQR)	1030.00 (777.83–1452.25)	1938.00 (1154.00–2997.50)	719.20 (349.50–1743.00)	2163.00 (2163.00–2163.00)
IL-6 (pg/mL), median (IQR)	6.40 (1.47–17.21)	16.93 (3.58–94.38)	1.94 (0.64–3.75)	5.41 (5.41–5.41)
SpO 2/ FiO 2, Median (IQR)	247.50 (112.94–412.50)	95.00 (91.50–105.56)	408.33 (376.58–412.50)	267.57 (267.57–267.57)