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. 2010 Feb 17;2010(2):CD006343. doi: 10.1002/14651858.CD006343.pub2

Comparison 1. Children with fever and neutropenia: lipid preparation of amphotericin B versus conventional amphotericin B.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Mortality (all cause) 1 95 Risk Ratio (M‐H, Random, 95% CI) 0.73 [0.17, 3.11]
2 Mortality (related to fungal infection) 1 95 Risk Ratio (M‐H, Random, 95% CI) 0.20 [0.01, 3.98]
3 Complete resolution of fungal infection 1 5 Risk Ratio (M‐H, Random, 95% CI) 1.5 [0.18, 12.46]
4 Partial resolution of fungal infection 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
5 Resolution of fever in suspected fungal infection 2 297 Risk Ratio (M‐H, Random, 95% CI) 1.23 [1.00, 1.52]
6 Progression of disease requiring change / addition of an antifungal agent 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
7 Breakthrough fungal infection requiring change / addition of an antifungal agent 3 345 Risk Ratio (M‐H, Random, 95% CI) 0.67 [0.24, 1.84]
8 Any clinically significant adverse reactions attributed to the antifungal agent resulting in discontinuation, dose reduction or change in therapy 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
9 Any clinically significant adverse reactions attributed to the antifungal agent (total) 2 299 Risk Ratio (M‐H, Random, 95% CI) 0.49 [0.21, 1.17]
10 Nephrotoxicity 4 371 Risk Ratio (M‐H, Random, 95% CI) 0.43 [0.21, 0.90]
11 Hypokalaemia 3 345 Risk Ratio (M‐H, Random, 95% CI) 0.71 [0.45, 1.14]
12 Hepatotoxicity 3 345 Risk Ratio (M‐H, Random, 95% CI) 1.12 [0.74, 1.71]
13 Infusion‐related reactions 2 284 Risk Ratio (M‐H, Random, 95% CI) 0.91 [0.59, 1.38]
13.1 Fever ‐ Liposomal AmB vs. Conventional Amphotericin B 1 96 Risk Ratio (M‐H, Random, 95% CI) 0.98 [0.86, 1.11]
13.2 Fever ‐ ABCD vs. Conventional Amphotericin B 1 46 Risk Ratio (M‐H, Random, 95% CI) 0.94 [0.69, 1.27]
13.3 Chills ‐ Liposomal AmB vs. Conventional Amphotericin B 1 96 Risk Ratio (M‐H, Random, 95% CI) 0.37 [0.21, 0.64]
13.4 Chills ‐ ABCD vs. Conventional Amphotericin B 1 46 Risk Ratio (M‐H, Random, 95% CI) 1.76 [1.09, 2.85]
14 Haematological disturbances 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
15 Neurological disturbances 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
16 Gastrointesitnal toxicity 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
17 Length of Stay 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
18 Quality of Life 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
19 Cost 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]