Comparison 3. Children with candidaemia or invasive candidiasis: micafungin versus liposomal amphotericin B.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mortality (all cause)	1	106	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.53, 2.02]
2 Mortality (related to fungal infection)	1	106	Risk Ratio (M‐H, Random, 95% CI)	1.38 [0.33, 5.89]
3 Complete resolution of fungal infection	1	84	Risk Ratio (M‐H, Random, 95% CI)	0.88 [0.68, 1.13]
3.1 Age < 2 years	1	43	Risk Ratio (M‐H, Random, 95% CI)	0.88 [0.64, 1.22]
3.2 Age 2 or older	1	41	Risk Ratio (M‐H, Random, 95% CI)	0.86 [0.57, 1.31]
4 Partial resolution of fungal infection	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
5 Resolution of fever in suspected fungal infection	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
6 Progression of disease requiring change / addition of an antifungal agent	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
7 Breakthrough fungal infection requiring change / addition of an antifungal agent	1	106	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
8 Any clinically significant adverse reactions attributed to the antifungal agent resulting in discontinuation, dose reduction or change in therapy	1	106	Risk Ratio (M‐H, Random, 95% CI)	0.35 [0.04, 3.22]
9 Any clinically significant adverse reactions attributed to the antifungal agent (total)	1	106	Risk Ratio (M‐H, Random, 95% CI)	0.86 [0.53, 1.38]
10 Nephrotoxicity	1	84	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
11 Hypokalaemia	1	106	Risk Ratio (M‐H, Random, 95% CI)	0.47 [0.18, 1.27]
12 Hepatotoxicity	1	57	Risk Ratio (M‐H, Random, 95% CI)	1.93 [0.19, 20.12]
13 Infusion‐related reactions	1	106	Risk Ratio (M‐H, Random, 95% CI)	0.73 [0.30, 1.77]
14 Gastrointestinal toxicity	1	212	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.49, 2.22]
14.1 Vomiting	1	106	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.46, 3.04]
14.2 Diarrhoea	1	106	Risk Ratio (M‐H, Random, 95% CI)	0.83 [0.24, 2.92]
15 Neurological disturbances	1	106	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
16 Haematological disturbances	1	106	Risk Ratio (M‐H, Random, 95% CI)	1.56 [0.60, 4.07]
17 Length of stay	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
18 Quality of life	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
19 Cost	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]