Reference
Dichotomous variables	Definition	Time point	Comparator A		Comparator B
			Number assessed	Number with outcome	Number assessed	Number with outcome
Primary outcomes
(1) All cause mortality	Death of any randomised patient regardless of cause	End of therapy
		Other time point ______________
(2) IFI related mortality	Death of a patient diagnosed with IFI whose death is attributable to IFI	End of therapy
		Other time point ______________
(3) Complete resolution of fungal infection	Complete resolution of clinical symptoms +/‐ radiological or microbiological findings that led to diagnosis of IFI and enabling cessation of anti‐fungal medication	End of therapy
Secondary outcomes
(4) Complete or partial resolution of fungal infection	Any improvement in clinical symptoms +/‐ radiological findings that led to diagnosis of IFI yet not fulfilling criteria for complete resolution	End of therapy
(5) Resolution of fever in suspected fungal infection	Absence of temperature > 38°C for more than 72 hours
(6) Progression of disease requiring change / addition of an antifungal agent	Progression of existing symptoms +/‐ radiological or microbiological findings that are of enough concern for a clinician to change anti‐fungal dose or add a new anti‐fungal agent
(7) Breakthrough fungal infection requiring change / addition of an antifungal agent	New clinical symptoms or signs +/‐ radiological or microbiological findings that are of enough concern for clinicians to change antifungal dose or add a new anti‐fungal agent
(8) Any clinically significant adverse reactions attributed to the antifungal agent resulting in discontinuation, dose reduction or change in therapy
(9) Any adverse reaction attributed to the antifungal agent including
(9a) Abnormal renal function	≥ 100% rise in serum creatinine
	Other definition of nephrotoxicity ________________________
(9b) electrolyte imbalance	hypokalaemia < 3.0mmol/L
	other definition of hypokalaemia
	other definitions of electrolyte imbalance
(9c) abnormal hepatic function	transaminases > 2x normal values for age
	Other definition of hepatotoxicity ________________________
(9d) infusion related reactions	Any infusion related reactions
	Chills (definition ______________________________________)
	Fevers (definition ______________________________________)
	Other infusion related reaction (definition _______________)
(9e) gastrointestinal disturbances such as nausea, vomiting or diarrhoea	Any gastrointestinal disturbances
	Nausea
	Vomiting
	Diarrhoea
(9f) neurological disturbances such as blurred vision or dizziness	Any neurological disturbances
	Blurred vision
	Dizziness
	Other neurological disturbances
(9g) Haematological disturbances such as anaemia, granulocytopaenia or thrombocytopaenia	Any haematological disturbances
	Anaemia (definition ___________________________________)
	Granulocytopaenia (definition __________________________)
	Thrombocytopaenia (definition _________________________)
Dichotomous variables	Definition	Time point	Comparator A		Comparator B
			Number assessed	Mean (SD)	Number assessed	Mean (SD)
Secondary outcomes
(10) Length of stay	number of days
(11) Quality of life	QOL (definition________________________________________)
(12) Cost	$US