Table 2.

Clinical Trials Questionnaire responses

Reason	Frequency of agreement (‘strongly agree’ or ‘agree to some extent’) with each reason for accepting or declining trial participation				Most important reason
	Acceptors n = 175	Decliners n = 21	χ2	P value	Acceptors n = 175	Decliners n = 18
I thought the trial offered the best treatment available	159 (91%)	6 (29%)	54.6	< 0.001a	35 (20%)	1 (6%)
I believed the benefits of treatment would out-weigh any side effects	142 (82%)b	1 (5%)	56.6	< 0.001	5 (3%)	0 (0%)
I was satisfied that either treatment in the trial would be suitable for me	141 (81%)	6 (29%)	27.0	< 0.001	7 (4%)	0 (0%)
I was worried that my illness would get worse unless I joined the study	29 (17%)	1 (5%)b	1.8	0.3a	0 (0%)	1 (6%)
The idea of randomisation worried me	84 (48%)	16 (76%)	6.0	0.02	1 (1%)	3 (17%)
I wanted the doctor to choose my treatment rather than be randomised by computer	69 (39%)	15 (71%)	7.8	0.005	0 (0%)	1 (5%)
The doctor told me what I needed to know about the trial	171 (98%)	19 (91%)	3.3	0.1a	0 (0%)	0 (0%)
I trusted the doctor treating me	173 (99%)	19 (95%)b	1.8	0.3a	7 (4%)	0 (0%)
I was given too much information to read about the trial	29 (17%)	0 (0%)	4.1	0.05a	0 (0%)	0 (0%)
I was given enough information to read about the trial	170 (97%)	17 (81%)	11.2	0.009a	6 (3%)	3 (17%)
I knew I could leave the trial at any time and still be treated	175 (100%)	18 (86%)	25.4	< 0.001a	23 (13%)	2 (11%)
I did not feel able to say no	13 (7%)	1 (5%)	0.2	1.000a	0 (0%)	0 (0%)
I wanted to help the doctors research	166 (95%)	11 (55%)b	34.0	< 0.001a	34 (19%)	1 (6%)
I feel that others with my illness will benefit from results of the trial	174 (99%)	12 (57%)	69.0	< 0.001a	55 (31%)	0 (0%)
The doctor wanted me to join the trial	62 (35%)	5 (25%)b	0.9	0.4	1 (1%)	1 (6%)
Others (e.g. family or friends) wanted me to join the trial	83 (47%)	1 (5%)	13.9	< 0.001	1 (1%)	5 (28%)

^aFisher’s exact test

^b1 missing response