Table 3.
Twenty Serum Metabolites Concentration and VIP Scores Between the T2DM Group and DPN Group
| Metabolites (μmol/g) | T2DM (n=18) | DPN (n=18) | VIP Score | P value | Q Value |
|---|---|---|---|---|---|
| Formate | 0.1775±0.0268 | 0.1140±0.0191 | 3.2218 | <0.001 | <0.001 |
| Hypoxanthine | 0.0743±0.0305 | 0.0839±0.0322 | 0.7405 | 0.365 | 0.662 |
| Histidine | 0.0688±0.0155 | 0.0697±0.0121 | 0.0397 | 0.862 | 0.973 |
| Phenylalanine | 0.0805±0.0221 | 0.0897±0.0299 | 0.4876 | 0.303 | 0.604 |
| Tyrosine | 0.0674±0.0135 | 0.0672±0.0267 | 0.0321 | 0.975 | 0.973 |
| Glucose | 6.3320±1.3424 | 6.7461±0.8703 | 0.6374 | 0.280 | 0.604 |
| Lactate | 5.4616±1.2861 | 6.3698±1.9338 | 1.3193 | 0.108 | 0.539 |
| Creatine | 0.1025±0.0186 | 0.0874±0.0162 | 1.5719 | 0.014 | 0.140 |
| Citrate | 0.1298±0.0341 | 0.1223±0.0402 | 0.2549 | 0.551 | 0.687 |
| Glutamine | 0.6328±0.1161 | 0.6557±0.1061 | 0.3682 | 0.540 | 0.687 |
| Acetate | 0.1047±0.0362 | 0.0957±0.0381 | 0.3952 | 0.474 | 0.677 |
| Alanine | 0.5151±0.1708 | 0.5171±0.1623 | 0.0010 | 0.972 | 0.973 |
| Valine | 0.3330±0.0656 | 0.3079±0.0622 | 0.7094 | 0.248 | 0.604 |
| Isoleucine | 0.1706±0.0395 | 0.1574±0.0344 | 0.7523 | 0.292 | 0.604 |
| Leucine | 0.1600±0.0327 | 0.1519±0.0347 | 0.4902 | 0.474 | 0.677 |
| 3-Hydroxybutyrate | 0.2553±0.0684 | 0.2278±0.0513 | 0.7610 | 0.182 | 0.604 |
| Tryptophan | 0.0537±0.0123 | 0.0491±0.0120 | 0.9177 | 0.259 | 0.604 |
| Inosine | 0.0151±0.0043 | 0.0150±0.0032 | 0.0945 | 0.938 | 0.973 |
| Ca2+ | 1.0747±0.1558 | 1.1191±0.2089 | 0.4073 | 0.475 | 0.677 |
| Mg2+ | 0.3242±0.0939 | 0.3782±0.0910 | 0.9755 | 0.089 | 0.539 |
Notes: Data presented are given in μmol/g (mean ± SD). P values were derived from independent sample t-test and then corrected via the Benjamini & Hochberg method for multiple sampling (Q values). VIP represents variable importance in projection, VIP scores were obtained from the OPLS-DA model.