Table 3. GSEA analysis of the TCGA-BRCA dataset.
| Description | Set size | Enrichment score | NES | p value | p. adjust |
|---|---|---|---|---|---|
| Condensation of prophase chromosomes | 72 | 0.648142653 | 2.609133444 | 0.000384468 | 0.007527598 |
| DNA methylation | 63 | 0.64924649 | 2.550957964 | 0.000368053 | 0.007527598 |
| Deposition of new cenpa containing nucleosomes at the centromere | 73 | 0.62272815 | 2.511036721 | 0.000387747 | 0.007527598 |
| Meiotic recombination | 85 | 0.597551004 | 2.469681726 | 0.000414594 | 0.007527598 |
| SIRT1 negatively regulates rrna expression | 66 | 0.615267088 | 2.433992405 | 0.000374532 | 0.007527598 |
| PRC2 methylates histones and DNA | 71 | 0.599962935 | 2.413657315 | 0.000381825 | 0.007527598 |
| Activated PKN1 stimulates transcription of AR androgen receptor regulated genes KLK2 and KLK3 | 65 | 0.598544909 | 2.36548707 | 0.000370508 | 0.007527598 |
| Recognition and association of DNA glycosylase with site containing an affected purine | 56 | 0.603186125 | 2.318484147 | 0.000351 | 0.007527598 |
| DNA damage telomere stress induced senescence | 80 | 0.563392337 | 2.306378423 | 0.000403551 | 0.007527598 |
| Mitotic prophase | 141 | 0.504722456 | 2.267243796 | 0.000542005 | 0.008140373 |
| Nonhomologous end joining NHEJ | 69 | 0.566496673 | 2.266201035 | 0.000376223 | 0.007527598 |
| Pre NOTCH expression and processing | 107 | 0.467738962 | 2.020954761 | 0.000458295 | 0.007527598 |
| Signaling by NOTCH | 234 | 0.287501505 | 1.378143085 | 0.003220612 | 0.03396672 |
| TCF dependent signaling in response to WNT | 232 | 0.286479654 | 1.373337984 | 0.006405124 | 0.058235094 |
| Signaling by WNT | 329 | 0.262444276 | 1.302165188 | 0.006944444 | 0.060142944 |
Notes.
- GSEA
- Gene Set Enrichment Analysis
- TCGA
- The Cancer Genome Atlas
- BRCA
- breast invasive carcinoma