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. 2023 Oct 11;11:e15475. doi: 10.7717/peerj.15475

Table 3. GSEA analysis of the TCGA-BRCA dataset.

Description Set size Enrichment score NES p value p. adjust
Condensation of prophase chromosomes 72 0.648142653 2.609133444 0.000384468 0.007527598
DNA methylation 63 0.64924649 2.550957964 0.000368053 0.007527598
Deposition of new cenpa containing nucleosomes at the centromere 73 0.62272815 2.511036721 0.000387747 0.007527598
Meiotic recombination 85 0.597551004 2.469681726 0.000414594 0.007527598
SIRT1 negatively regulates rrna expression 66 0.615267088 2.433992405 0.000374532 0.007527598
PRC2 methylates histones and DNA 71 0.599962935 2.413657315 0.000381825 0.007527598
Activated PKN1 stimulates transcription of AR androgen receptor regulated genes KLK2 and KLK3 65 0.598544909 2.36548707 0.000370508 0.007527598
Recognition and association of DNA glycosylase with site containing an affected purine 56 0.603186125 2.318484147 0.000351 0.007527598
DNA damage telomere stress induced senescence 80 0.563392337 2.306378423 0.000403551 0.007527598
Mitotic prophase 141 0.504722456 2.267243796 0.000542005 0.008140373
Nonhomologous end joining NHEJ 69 0.566496673 2.266201035 0.000376223 0.007527598
Pre NOTCH expression and processing 107 0.467738962 2.020954761 0.000458295 0.007527598
Signaling by NOTCH 234 0.287501505 1.378143085 0.003220612 0.03396672
TCF dependent signaling in response to WNT 232 0.286479654 1.373337984 0.006405124 0.058235094
Signaling by WNT 329 0.262444276 1.302165188 0.006944444 0.060142944

Notes.

GSEA
Gene Set Enrichment Analysis
TCGA
The Cancer Genome Atlas
BRCA
breast invasive carcinoma