Gomez‐Perez 1985.

Methods	Double blind placebo controlled crossover study, 30 days. Two 30 days periods, no washout. No analyses of carry over effect Dose escalation during the first week Randomisation method not stated
Participants	Diabetic neuropathy. 24 participants (18 final number). Mean age 55 (range 30 to 73), 9 male and 9 female patients
Interventions	Nortriptyline dose escalation from 30 mg to 60 mg and fluphenazine from 1.5 mg to 3 mg daily orally, or placebo daily orally
Outcomes	Pain patients reported, pain relief 50% or more, VAS change from baseline Pain relief on active treatment 16/18 , on placebo 1/18 Pain decreased 63.97 % on active treatment, 22.11 % on placebo
Notes	Dropouts 6/24 (one ketoacidosis, 2 lack of compliance, 3 lost to follow‐up) No withdrawals due to SE QS = 4 (R1, DB2, W1)
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear