Lampl 2002.

Methods	Double blind placebo controlled parallel design study for one year
Participants	Prophylaxis of central post stroke pain after thalamic stroke. 39 participants age 36 to 68
Interventions	Amitriptyline extended release, 10 to 75 mg daily or placebo for one year
Outcomes	Time to event (pain), Pain intensity, type, site and distribution. Presence/absence of allodynia. AES Average time to pain: placebo 318 days (SE 23) amitriptyline 324 days (SE 24) Number experiencing pain 3/20 amitriptyline, 4/19 placebo
Notes	Two moderate AEs in amitriptyline group requiring dose reduction. two withdrew due to protocol violations QS = 4 (R1, DB2, W1)
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear