Robinson 2004.

Methods	Randomised double blind placebo controlled parallel group study, six weeks treatment
Participants	39 participants age 22 to 65 years, Amputation related pain of > 6 months. Average pain at least 2 on 11 point scale
Interventions	Amitriptyline 10 mg / day up to 125 mg/day. Active placebo (benztropine 0.5 mg) dose not escalated
Outcomes	Pt reported average PI on 11 pt scale. SF McGill, unmodified BPI, depression scale. Functional ability assessment, satisfaction with life Amitriptyline was not different from placebo for phantom limb pain or residual limb pain. No sig diff in depression scores between amitriptyline and placebo
Notes	Two withdrew in amitriptyline group due to AEs. Dry mouth, dizziness commonly reported QS = 4 (R1, DB2, W1)
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear