Study	Reason for exclusion
Andersen 1993	Comorbidity (stroke)
Bakish 1992	Not a primary care setting
Barrett 1999	Study included secondary care patients as well as primary care patients
Barrrett 2001	Treatment in this study was undertaken by psychiatrists
Borsun 1992	Comborbidity (COPD)
Gomez 1968	Compared amitriptyline with an antipsychotic
Houston 1983	Used the Leeds depression scale
Jacobs 1965	A monoamine oxidase inhibitor
Katz 2005	All medications combined, no single drug vs placebo
Laakman 1995	Patients from psychiatrists and outpatient clinics
Lehmann 1976	Not a true RCT (a CCT)
Montgomery 1998	Patients were from psychiatrists (i.e., not in primary care setting)
O'Hara 1978	Maprotiline compared with fluphenazine/nortriptyline; placebo was also used, but delivered in combination with active treatments and not as a comparator
Paykel 1988	Primary data presented in Hollyman 1988 (see Characteristics of included studies table)
Rickels 1968	Iprindole not in current clinical use
Rickels 1971	No single antidepressant vs placebo
Rickels 1991	Not primary care setting
Schiffer 1975	No single antidepressant vs placebo
SCTG 1985	Patients were of a mixed population (both anxiety and depression)
Thompson 1994	Examined data originating from Doogan 1994 (included in this review)