Table 1.

Multivariable Mendelian randomization models^a of apolipoprotein B plus lipid variables and risk of an CHD event

Multivariable MR models	CHD causal effect estimate		P value
	OR per unit change (95% CI)b	OR per Sd change (95% CI)c
Model 1
ApoB	2.99 (2.32–3.85)	1.29 (1.22–1.37)	2.0 × 10−17
TRL/remnant-C	2.47 (1.90–3.21)	1.34 (1.23–1.46)	1.9 × 10−11
Model 2
LDL-C	1.37 (1.27–1.48)	1.29 (1.22–1.38)	4.0 × 10−16
TRL/remnant-C	2.59 (1.99–3.36)	1.36 (1.25–1.48)	1.2 × 10−12

ApoB, apolipoprotein B; CI, confidence interval; GWAS, genome-wide association study; LDL-C, low-density lipoprotein cholesterol; MR, Mendelian randomization; OR, odds ratio; Sd, standard deviation; SNP, single-nucleotide polymorphism; remnant-C, remnant cholesterol; TG, triglycerides; TRL, triglyceride-rich lipoprotein.

Multivariable randomization models used the 1125 SNPs identified by GWAS and the inverse variance–weighted method for odds ratio calculation. The potential impact of SNP pleiotropic effects was tested as set out in Supplementary data online, Table S5. The subject cohort used in this analysis involved all subjects in whom TRL/remnant-C could be determined.

OR per 1.0 g/L change in apoB or per 1.0 mmol/L change in TG, LDL-C, and TRL/remnant-C.

OR per population Sd change in respective variable (apoB Sd, 0.23 g/L; TRL/remnant-C Sd, 0.30 mmol/L; LDL-C Sd, 0.82 mmol/L).