Table 1.

Clinical and sociodemographic characteristics of the sample

	PreHD (n = 33)	HD-NC (n = 52)	HD-MCI (n = 49)	HD-Dem (n = 46)	P
Age	40.9 ± 8.7	49.5 ± 9.6	52.3 ± 11.1	53.2 ± 13.4	a0.003; b< 0.001; c< 0.001: d0.585; e0.340; f< 0.974
Gender (female/male)	25/8	33/19	23/26	23/23	aχ = a0.235; b0.009; c0.021: d0.095; e0.179; f< 0.765
Education	14.5 ± 4.4	14.4 ± 3.3	11.2 ± 4.0	9.5 ± 3.8	a0.999; b0.001; c< 0.001; d< 0.001; e< 0.001; f< 0.126
CAG	42.7 ± 2.5	42.8 ± 2.4	43.4 ± 2.3	44.3 ± 3.7	a0.993; b0.702; c0.069: d0.782; e0.059; f< 0.388
DBS1	288.4 ± 98.5	349.1 ± 81.9	394.3 ± 97.9	430.6 ± 113.9	a0.036; b< 0.001; c< 0.001: d0.102; e< 0.001; f0.281
UHDRS-TMS2	1.1 ± 1.6	16.8 ± 11.2	35.5 ± 15.0	47.9 ± 19.7	a< 0.001; b< 0.001; c< 0.001: d< 0.001; e < 0.001; f < 0.001
TFC3	12.9 ± 0.4	12.1 ± 1.0	9.9 ± 1.6	7.1 ± 2.7	a0.162; b< 0.001; c< 0.001: d< 0.001; e< 0.001; f< 0.001
Disease stage
Premanifest	33	–	–	–
Stage I	–	49	21	2
Stage II	–	3	28	34
Stage III	–	–	–	10

¹Disease burden score

²Unified Huntington’s disease rating scale-Total motor score

³Total functional capacity

⁴Mini-mental state examination

⁵Parkinson’s Disease-Cognitive Rating Scale

^aPreHD vs HD-NC

^bPreHD vs HD-MCI

^cPreHD vs HD-Dem

^dHD-NC vs HD-MCI

^eHD-NC vs HD-Dem

^fHD-MCI vs HD-Dem