Table 2.

Linear mixed-effects models with covariables (age, education and UHDRS)

	PreHD					HD-NC
	Baseline	6 months	12 months	P global	P dif groups	Baseline	6 months	12 months	P global	P dif groups
PD-CRS5 total score	105.7 ± 1.9	107.7 ± 1.9	106.6 ± 2.2	0.211	0.438/1.000/1.000	93.2 ± 1.6	95.6 ± 2.2	92.6 ± 2.2	0.101	0.090/0.654/0.043
MMSE4	28.8 ± 0.3	29.4 ± 0.4	28.9 ± 0.4	0.204	0.249/1.000/0.953	28.4 ± 0.2	28.5 ± 0.4	28.5 ± 0.3	0.944	0.842/0.753/0.965
UHDRS Cogscore	262.3 ± 6.5	269.5 ± 7.7	262.1 ± 7.1	0.443	1.000/1.000/0.657	211.2 ± 7.0	216 ± 7.5	206 ± 7.9	0.286	0.984/0.140/0.215

	HD-MCI					HD-DEM
	Baseline	6 months	12 months	P global	P dif groups	Baseline	6 months	12 months	P global	P dif groups
PD-CRS5 total score	72.9 ± 1.5	72.3 ± 2.2	67.0 ± 2.1	0.003	0.679/0.001/0.019	46.8 ± 1.6	45.4 ± 1.8	41.8 ± 1.7	0.003	0.387/0.001/0.021
MMSE4	25.9 ± 0.3	24.3 ± 1.4	25.3 ± 0.4	0.189	0.202/0.085/0.369	22.3 ± 0.5	22.7 ± 0.7	21.0 ± 0.6	0.042	0.390/0.027/0.014
UHDRS Cogscore	142.6 ± 6.1	140.6 ± 7.8	133.1 ± 7.2	0.076	0.715/0.023/0.203	88.6 ± 4.6	81.1 ± 5.9	77.6 ± 6.8	0.231	0.180/0.103/0.538