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. 2023 Jul 18;270(11):5408–5417. doi: 10.1007/s00415-023-11804-0

Table 3.

Minimally Clinically Important Difference (MCID) for each group, timepoint, and instrument

preHD Overall sample (symptomatic) HD-NC HD-MCI HD-Dem
6-month 12-month 6-month 12-month 6-month 12-month 6-month 12-month 6-month 12-month
PD-CRS 9.8 10.7 9.9 13.4 12.6 10.8 9.4 15.8 10.5 13.8
MMSE 3.7 3.4 5.9 4.3 3.7 3 8.9 4 3.9 5.9
Cogscore 45.2 20.8 22.8 29.3 19.3 24 23.3 29.8 28.6 40.1