Fig. 2.

Improvement of clinical scores for breast cancer by their combination with a PRS. PRS: polygenic risk score, AUC: area under the receiver operating characteristic curve. For details on individual studies, see Supplementary Table S1. BOADICEA + risk factors (Choudhury et al. 2021) was excluded because no AUC was available. The y axis only starts at 0.5 because any smaller AUC would imply that the corresponding score is worse in assigning disease status (affected, not-affected) than flipping a coin